Confirmation of eosinophilic sialodochitis by terminal duct biopsy

• Published in: Oral diseases Vol. 30; no. 5; pp. 3056 - 3065
• Main Authors: Zheng, Dan‐Ni, Ling, Xiao‐Tong, Qu, Liu‐Yang, Yang, Jing, Zhang, Jian‐Yun, Chen, Yan, Liu, Deng‐Gao, Yu, Guang‐Yan
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.07.2024
• Subjects: Adolescent; Adult; Aged; Biopsy; Degranulation; diagnosis; Endoscopy; Eosinophilia - pathology; eosinophilic sialodochitis; Eosinophils - pathology; Female; Fibrosis; Humans; Immunoglobulin E; Leukocytes (eosinophilic); Lymphocytes; Male; Middle Aged; pathology; Peripheral blood; Prospective Studies; Salivary Ducts - pathology; sialadenitis; Sialadenitis - diagnosis; Sialadenitis - pathology; Young Adult; biopsy; diagnosis; endoscopy; eosinophilic sialodochitis; pathology; sialadenitis
• ISSN: 1354-523X; 1601-0825; 1601-0825
• DOI: 10.1111/odi.14753

Objective To analyse the histopathological features of eosinophilic sialodochitis by using terminal duct biopsy. Methods Sixty‐five patients with suspected eosinophilic sialodochitis and four with chronic obstructive sialadenitis were prospectively enrolled. Clinical features, laboratory tests and sialograms were comparatively analysed. Terminal duct biopsy of the parotid or submandibular glands was performed concomitantly with endoscopy‐assisted duct dilatation to determine the histopathological features of eosinophilic sialodochitis. Results Based on eosinophil quantification, the samples of suspected patients were scored as ‘definite’, ‘highly suspected’ and ‘negative’ in 26 (40%), 15 (23.1%) and 24 (36.9%) cases, respectively. Gland types and peripheral blood eosinophil counts were significantly different among these three groups. The proportions of itching glands, mucus plug exudations and elevated immunoglobulin E levels were higher in the ‘definite’ group than in the other two groups; however, the intergroup differences were insignificant. The primary pathological features of eosinophilic sialodochitis were abundant eosinophils and lymphocytes infiltrated around the duct, degranulation of eosinophils, extensive fibrosis and scattered mastocytes. Periductal eosinophils were not found in cases of chronic obstructive sialadenitis. Conclusion Our findings suggest that terminal duct biopsy is safe and valuable for the pathological confirmation of eosinophilic sialodochitis, and can be used simultaneously with endoscopy‐assisted duct dilatation.