The association between liver cirrhosis and fracture risk: A systematic review and meta‐analysis

Summary Objective Liver cirrhosis (LC) was associated with an increased risk of osteoporosis; however, the association between LC and fracture risk was inconclusive. Therefore, this systematic review and meta‐analysis aims to explore the association between LC and fracture risk. Design To identify r...

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Published inClinical endocrinology (Oxford) Vol. 89; no. 4; pp. 408 - 413
Main Authors Liang, Jie, Meng, Wei‐Dong, Yang, Jun‐Ming, Li, Sheng‐Long, Zhong, Mi‐Na, Hou, Xuan‐Xuan, Wang, Ran, Long, Yu‐Ying, Bao, Liang‐Xiao, Bao, Ming
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.10.2018
Subjects
Animals
Cirrhosis
Confidence Intervals
fracture
Fractures
Fractures, Bone - epidemiology
Health risk assessment
Hip
Hip Fractures - epidemiology
Humans
Liver
Liver cirrhosis
Liver Cirrhosis - epidemiology
Meta-analysis
Odds Ratio
Osteoporosis
primary biliary cirrhosis
Risk Factors
Spine
Systematic review
meta-analysis
primary biliary cirrhosis
cirrhosis
fracture
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Summary:Summary Objective Liver cirrhosis (LC) was associated with an increased risk of osteoporosis; however, the association between LC and fracture risk was inconclusive. Therefore, this systematic review and meta‐analysis aims to explore the association between LC and fracture risk. Design To identify related literature, a systematic search of PubMed, EMBASE, Web of science and the Cochrane Library from 1965 to July 2017 without language limitation was performed. The random‐effects model described by DerSimonian and Laird was used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs). Results Eventually, 5 cohort and 3 case‐control studies were identified, which included 321 035 subjects and 31 272 fracture cases. The pooled OR of the association between LC and any fracture risk, hip fracture, spine/trunk fracture and limb fracture was 1.94 (95% CI, 1.59‐2.37), 2.11 (95% CI, 1.34‐3.32), 2.00 (95% CI, 1.50‐2.67) and 1.82 (95% CI, 1.65‐2.01), respectively. Conclusion In conclusion, this study indicates that cirrhotic patients have an increased risk of fracture. Preventive measures should be instituted as early as possible.
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ISSN:0300-0664
1365-2265
1365-2265
DOI:10.1111/cen.13762