Prognostic role of the Donor Risk Index, the Eurotransplant Donor Risk Index, and the Balance of Risk score on graft loss after liver transplantation

• Published in: Transplant international Vol. 34; no. 5; pp. 778 - 800
• Main Authors: Lozanovski, Vladimir J., Probst, Pascal, Arefidoust, Alireza, Ramouz, Ali, Aminizadeh, Ehsan, Nikdad, Mohammadsadegh, Khajeh, Elias, Ghamarnejad, Omid, Shafiei, Saeed, Ali‐Hasan‐Al‐Saegh, Sadeq, Seide, Svenja E., Kalkum, Eva, Nickkholgh, Arash, Czigany, Zoltan, Lurje, Georg, Mieth, Markus, Mehrabi, Arianeb
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.05.2021
• Subjects: balance of risk score; Calibration; Confidence intervals; donor risk index; Eurotransplant; graft loss; Grafting; Liver; Liver transplantation; Liver transplants; major extended donor criteria; Risk; Transplantation; Eurotransplant; donor risk index; balance of risk score; graft loss; liver transplantation; major extended donor criteria
• ISSN: 0934-0874; 1432-2277
• DOI: 10.1111/tri.13861

Summary This study aimed to identify cutoff values for donor risk index (DRI), Eurotransplant (ET)‐DRI, and balance of risk (BAR) scores that predict the risk of liver graft loss. MEDLINE and Web of Science databases were searched systematically and unrestrictedly. Graft loss odds ratios and 95% confidence intervals were assessed by meta‐analyses using Mantel–Haenszel tests with a random‐effects model. Cutoff values for predicting graft loss at 3 months, 1 year, and 3 years were analyzed for each of the scores. Measures of calibration and discrimination used in studies validating the DRI and the ET‐DRI were summarized. DRI ≥ 1.4 (six studies, n = 35 580 patients) and ET‐DRI ≥ 1.4 (four studies, n = 11 666 patients) were associated with the highest risk of graft loss at all time points. BAR > 18 was associated with the highest risk of 3‐month and 1‐year graft loss (n = 6499 patients). A DRI cutoff of 1.8 and an ET‐DRI cutoff of 1.7 were estimated using a summary receiver operator characteristic curve, but the sensitivity and specificity of these cutoff values were low. A DRI and ET‐DRI score ≥ 1.4 and a BAR score > 18 have a negative influence on graft survival, but these cutoff values are not well suited for predicting graft loss.