Contrast‐induced encephalopathy following cardiac catheterization

• Published in: Catheterization and cardiovascular interventions Vol. 90; no. 2; pp. 257 - 268
• Main Authors: Spina, Roberto, Simon, Neil, Markus, Romesh, Muller, David WM, Kathir, Krishna
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.08.2017
• Subjects: Adult; Aged; Aged, 80 and over; Angiography; Aphasia; Blindness; Blood-brain barrier; Brain; Brain Diseases - chemically induced; Brain Diseases - diagnosis; Brain Diseases - physiopathology; Brain Diseases - therapy; Cardiac catheterization; Cardiac Catheterization - adverse effects; Catheterization; Catheters; complications of cardiac catheterization; Computed tomography; Contrast Media - administration & dosage; Contrast Media - adverse effects; contrast‐induced encephalopathy; Coronary Angiography - adverse effects; Diabetes mellitus; Diagnosis, Differential; Differential diagnosis; Diffusion coefficient; Disruption; Disturbance; Encephalopathy; Epidemiology; Female; Grafts; Health risks; Heart; Heart diseases; Humans; Infant; Intubation; iodine neurotoxicity; Ischemia; Kidneys; Magnetic resonance imaging; Male; Medical imaging; Medical personnel; Middle Aged; Motor task performance; Neuroimaging; NMR; Nuclear magnetic resonance; Predictive Value of Tests; Prognosis; Radiography, Interventional - adverse effects; Renal function; Reviews; Risk Assessment; Risk Factors; Seizures; Side effects; Stroke; Stroke - diagnosis; Time Factors; transient cortical blindess; Treatment Outcome; Vasoconstriction; transient cortical blindess; contrast-induced encephalopathy; stroke; iodine neurotoxicity; complications of cardiac catheterization
• ISSN: 1522-1946; 1522-726X
• DOI: 10.1002/ccd.26871

Objectives To describe the epidemiology, pathophysiology, clinical presentation, and management of contrast‐induced encephalopathy (CIE) following cardiac catheterization. Background CIE is an acute, reversible neurological disturbance directly attributable to the intra‐arterial administration of iodinated contrast medium. Methods The PubMed database was searched and all cases in the literature were retrieved and reviewed. Results 52 reports of CIE following cardiac catheterization were found. Encephalopathy, motor and sensory disturbances, vision disturbance, opthalmoplegia, aphasia, and seizures have been reported. Transient cortical blindness is the most commonly reported neurological syndrome, occurring in approximately 50% of cases. The putative mechanism involves disruption of the blood brain barrier and direct neuronal injury. Contrast‐induced transient vasoconstriction has also been implicated. Symptoms typically appear within minutes to hours of contrast administration and resolve entirely within 24–48 hr. Risk factors may include hypertension, diabetes mellitus, renal impairment, the administration of large volumes of iodinated contrast, percutaneous coronary intervention or selective angiography of internal mammary grafts, and previous adverse reaction to iodinated contrast. Characteristic findings on cerebral imaging include cortical and sub‐cortical contrast enhancement on computed tomography (CT). Imaging findings in CIE may mimic subarachnoid hemorrhage or cerebral ischemia; the Hounsfield scale on CT and the apparent diffusion coefficient on magnetic resonance imaging (MRI) are useful imaging tools in distinguishing these entities. In some cases, brain imaging is normal. Prognosis is excellent with supportive management alone. CIE tends to recur, although re‐challenge with iodinated contrast without adverse effects has been documented. Conclusions CIE is an important clinical entity to consider in the differential diagnosis of stroke following cardiac catheterization. Given that prognosis is excellent with supportive management only, physicians should be aware of it, and consider it prior to initiating thrombolysis. © 2016 Wiley Periodicals, Inc.