Sodium–glucose cotransporter inhibitors and oxidative stress: An update

• Published in: Journal of cellular physiology Vol. 234; no. 4; pp. 3231 - 3237
• Main Authors: Yaribeygi, Habib, Atkin, Stephen L., Butler, Alexandra E., Sahebkar, Amirhossein
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2019
• Subjects: Animals; Antioxidants; Antioxidants - metabolism; Antioxidants - therapeutic use; Arteriosclerosis; Atherosclerosis; Blood Glucose - drug effects; Blood Glucose - metabolism; Cardiovascular Diseases - drug therapy; Cardiovascular Diseases - metabolism; Chemical compounds; Clinical trials; Diabetes; Diabetes mellitus; Diabetes Mellitus - drug therapy; Diabetes Mellitus - metabolism; Disease control; free radicals; Glucose; glycosuria; Humans; Inhibitors; Medical research; Oxidation; Oxidative stress; Oxidative Stress - drug effects; Pharmacology; Reactive Oxygen Species - metabolism; Reduction; SGLT2 inhibitors; Sodium; Sodium-glucose cotransporter; Sodium-Glucose Transporter 1 - metabolism; Sodium-Glucose Transporter 2 - metabolism; Sodium-Glucose Transporter 2 Inhibitors - therapeutic use; free radicals; diabetes; oxidative stress; SGLT2 inhibitors; glycosuria

Sodium–glucose cotransporter 2 (SGLT2) inhibitors are therapeutic agents that have been used recently to reduce tubular absorption of glucose, leading to enhanced glycosuria, resulting in the reduction of blood glucose and improved diabetes control. Recent data suggest that SGLT2 inhibitors have ant...