Functional disconnection of the semantic networks in schizophrenia

Patients with schizophrenia exhibit deficits in semantic processing, which can form the basis of thought disorders. The objective of this study was to explore functional connectivity between the activated areas during semantic processing in schizophrenia. Twelve patients with schizophrenia and 12 he...

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Bibliographic Details
Published inNeuroreport Vol. 16; no. 4; p. 355
Main Authors Kim, Jae-Jin, Ho Seok, Jeong, Park, Hae-Jeong, Soo Lee, Dong, Chul Lee, Myung, Kwon, Jun Soo
Format Journal Article
LanguageEnglish
Published England 15.03.2005
Subjects
Adult
Cerebral Cortex - physiology
Female
Humans
Male
Nerve Net - physiology
Photic Stimulation - methods
Positron-Emission Tomography - methods
Psychomotor Performance - physiology
Schizophrenia - physiopathology
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Summary:Patients with schizophrenia exhibit deficits in semantic processing, which can form the basis of thought disorders. The objective of this study was to explore functional connectivity between the activated areas during semantic processing in schizophrenia. Twelve patients with schizophrenia and 12 healthy controls were studied with [15O]H2O positron-emission tomography during semantic judgment. The expected activation in the left inferior occipitotemporal cortex significantly correlated with several other regional activations in normal study participants, but with no other regional activations in patients with schizophrenia. This finding suggests that schizophrenia involves a disconnection of semantic networks. The resultant distortion in semantic processing may have an impact on thought disorders.
ISSN:0959-4965
DOI:10.1097/00001756-200503150-00010