Pharmacokinetics of peramivir after single intravenous doses in healthy Chinese subjects

• Published in: Xenobiotica Vol. 45; no. 3; pp. 239 - 243
• Main Authors: Zhang, Dan, Du, Aihua, Zhang, Lina, Ma, Jingyi, Meng, Lingjie, Deng, Ming, Xu, Juan, Liu, Huichen
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.03.2015; Informa Healthcare
• Subjects: Administration, Intravenous; Adult; Asian Continental Ancestry Group; China; Chinese subjects; Cyclopentanes - administration & dosage; Cyclopentanes - blood; Cyclopentanes - chemistry; Cyclopentanes - pharmacokinetics; Demography; Dose-Response Relationship, Drug; Female; Guanidines - administration & dosage; Guanidines - blood; Guanidines - chemistry; Guanidines - pharmacokinetics; Healthy Volunteers; Humans; intravenous infusion; Male; peramivir; pharmacokinetics; plasma; urine; Young Adult; China; pharmacokinetics; peramivir; intravenous infusion; plasma; Chinese subjects; urine
• ISSN: 0049-8254; 1366-5928; 1366-5928
• DOI: 10.3109/00498254.2014.960907

Abstract 1. The aim of the study was to evaluate the pharmacokinetics of peramivir after single intravenous (i.v.) doses in healthy Chinese subjects. 2. In a cross-over study, 12 subjects were given 300 and 600 mg peramivir by i.v. infusion. Blood and urine samples were collected at 17 designated time points and 7 designated intervals up to 36 h post-dose. Plasma and urine concentrations of peramivir were quantified by LC-MS/MS. 3. After single i.v. doses of 300 and 600 mg peramivir, Cmax and AUC0-t of peramivir were 21.4 ± 3.7, 41.1 ± 5.3 mg L−1 and 55.90 ± 10.62, 112.1 ± 13.2 mg h L−1, respectively. Cmax and AUC increased in proportion to the dose. Within 12 h, accumulative urinary recoveries of peramivir after single i.v. doses of 300 and 600 mg peramivir were 84.31 ± 11.75% and 88.10 ± 7.39%, respectively. 4. In healthy Chinese subjects, peramivir displayed linear pharmacokinetics in the range of 300-600 mg, and was primarily excreted via urine as unchanged drug.