Plant immunity: the EDS1 regulatory node

• Published in: Current opinion in plant biology Vol. 8; no. 4; pp. 383 - 389
• Main Authors: Wiermer, Marcel, Feys, Bart J, Parker, Jane E
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2005
• Subjects: Arabidopsis - immunology; Arabidopsis - metabolism; Arabidopsis Proteins - metabolism; Arabidopsis Proteins - physiology; binding proteins; Carboxylic Ester Hydrolases - metabolism; Carboxylic Ester Hydrolases - physiology; defense mechanisms; disease resistance; DNA-Binding Proteins - metabolism; DNA-Binding Proteins - physiology; enhanced disease susceptibility 1 protein; Gene Expression Regulation, Plant; host-pathogen relationships; literature reviews; Oxidative Stress; Plant Diseases; plant diseases and disorders; plants; protein-protein interactions; regulatory proteins; Signal Transduction
• ISSN: 1369-5266; 1879-0356
• DOI: 10.1016/j.pbi.2005.05.010

ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) and its interacting partner, PHYTOALEXIN DEFICIENT 4 (PAD4), constitute a regulatory hub that is essential for basal resistance to invasive biotrophic and hemi-biotrophic pathogens. EDS1 and PAD4 are also recruited by Toll-Interleukin-1 receptor (TIR)-type nucleotide binding-leucine rich repeat (NB-LRR) proteins to signal isolate-specific pathogen recognition. Recent work points to a fundamental role of EDS1 and PAD4 in transducing redox signals in response to certain biotic and abiotic stresses. These intracellular proteins are important activators of salicylic acid (SA) signaling and also mediate antagonism between the jasmonic acid (JA) and ethylene (ET) defense response pathways. EDS1 forms several molecularly and spatially distinct complexes with PAD4 and a newly discovered in vivo signaling partner, SENESCENCE ASSOCIATED GENE 101 (SAG101). Together, EDS1, PAD4 and SAG101 provide a major barrier to infection by both host-adapted and non-host pathogens.