Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic Drug

• Published in: Nanoscale research letters Vol. 5; no. 4; pp. 781 - 785
• Main Authors: Cao, Shao-Wen, Zhu, Ying-Jie, Wu, Jin, Wang, Ke-Wei, Tang, Qi-Li
• Format: Journal Article
• Language: English
• Published: New York Springer New York 14.02.2010; Springer
• Subjects: Chemistry and Materials Science; Materials Science; Molecular Medicine; Nano Express; Nanochemistry; Nanoscale Science and Technology; Nanotechnology; Nanotechnology and Microengineering; Calcium phosphate; Sustained release; Nanocomposite; Hydrophobic drug; P123
• ISSN: 1931-7573; 1556-276X
• DOI: 10.1007/s11671-010-9558-5

The P123/ACP nanocomposite with sizes less than 100 nm consisting of triblock copolymer P123 and amorphous calcium phosphate (ACP) has been prepared by using an aqueous solution containing CaCl 2 , (NH 4 ) 3 PO 4 , and P123 at room temperature. The P123/ACP nanocomposite is used as the nanocarrier for hydrophobic drug ibuprofen, based on the combined advantages of both amphiphilic block copolymer and calcium phosphate delivery system. The P123/ACP nanocomposite has a much higher ibuprofen loading capacity (148 mg/g) than the single-phase calcium phosphate nanostructures. The drug release percentage of the P123/ACP nanocomposite in simulated body fluid reaches about 100% in a period of 156 h, which is much slower than that of single-phase calcium phosphate nanostructures. It is expected that the P123/ACP nanocomposite is promising for the application in the controlled delivery of hydrophobic drugs.