Cellular and molecular biological events at the implant interface

• Published in: Journal of cranio-maxillo-facial surgery Vol. 22; no. 1; pp. 12 - 17
• Main Authors: Bagambisa, Frank B., Kappert, Heinrich F., Schilli, Wilfried
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.02.1994; Elsevier
• Subjects: Actins - physiology; Animals; Biological and medical sciences; Cell Adhesion; Cell Line; Ceramics; Collagen; Extracellular Matrix - physiology; Extracellular Matrix - ultrastructure; Fibronectins - physiology; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics; Maxillofacial surgery. Dental surgery. Orthodontics; Medical sciences; Metals; Osseointegration; Osteoblasts - physiology; Osteoblasts - ultrastructure; Prostheses and Implants; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Human; Cell culture; Implant; Substance loss; Exploration; Histology; Experimental study; Fibronectin; Morphogenesis; Treatment; Surgery; Head and neck; ENT disease; Biomaterial; Molecular biology; Osseous tissue
• ISSN: 1010-5182; 1878-4119
• DOI: 10.1016/S1010-5182(05)80290-2

Since implants attain and maintain contact with the body environment through their surfaces, the interfacial interaction between implant bed and implant surface could be a determinant of the implant's performance. This study used osteoblasts to test the ability of different ceramic and metallic surfaces to bind fibronectin and to support cell attachment, adhesion, migration and synthesis of extracellular matrix. The results showed active molecular and cellular interaction between the cells and the surfaces. Extracellular matrix synthesis was demonstrated on surfaces that did not subject the cells to toxicity embarrassment. It is concluded that the surfaces of implants should not be designed to be mere bystanders in the interfacial scenario. Instead they should be conceived with a view to enabling them to interact positively with the molecules responsible for would healing, interfacial tissue morphogenesis and repair.