Avian Reovirus Proteins Associated with Neutralization of Virus Infectivity

Monoclonal antibodies against two virion proteins of the RAM-1 strain of avian reovirus neutralized virus infectivity; antibody against a 124-kDa (λB) protein caused broadly specific neutralization and antibody against a 39-kDa (σC) protein caused neutralization of greater type-specificity. The neut...

Full description

Saved in:
Bibliographic Details
Published inVirology (New York, N.Y.) Vol. 194; no. 2; pp. 688 - 696
Main Authors Wickramasinghe, Ranjit, Meanger, Jay, Enriquez, Carlos E., Wilcox, Graham E.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 01.06.1993
Elsevier
Subjects
Animals
Antibodies, Monoclonal - immunology
Antibodies, Viral - immunology
ANTICORPS MONOCLONAL
ANTICUERPOS MONOCLONALES
Biological and medical sciences
Cells, Cultured
Chickens - microbiology
CULTIVO DE CELULAS
CULTURE DE CELLULE
Fundamental and applied biological sciences. Psychology
Genetic Variation
Microbiology
Morphology, structure, chemical composition, physicochemical properties
Neutralization Tests
PODER PATOGENO
POUVOIR PATHOGENE
PROTEINAS
PROTEINE
REACCION ANTIGENO-ANTICUERPO
REACTION ANTIGENE ANTICORPS
RELACIONES HUESPED PARASITO
RELATION HOTE PARASITE
REOVIRIDAE
Reoviridae - immunology
Reoviridae - pathogenicity
Serotyping
Species Specificity
Viral Proteins - immunology
Virology
Virulence
VIRUS DE LOS ANIMALES
VIRUS DES ANIMAUX
Virus
Proteins
Infectivity
Host specificity
Monoclonal antibody
Infected cell
Avian reovirus
Reoviridae
Reovirus
Neutralization
Online AccessGet full text

Cover

More Information
Summary:Monoclonal antibodies against two virion proteins of the RAM-1 strain of avian reovirus neutralized virus infectivity; antibody against a 124-kDa (λB) protein caused broadly specific neutralization and antibody against a 39-kDa (σC) protein caused neutralization of greater type-specificity. The neutralizing activity of the monoclonals also exhibited host cell specificity: antibodies against the λB protein inhibited virus infectivity in Vero cells and not chicken kidney cells; one monoclonal antibody against the σC protein neutralized virus in only chicken kidney cells, whereas two other monoclonals against the σC protein neutralized virus in both Vero and chicken kidney cells but had greater neutralizing activity in Vero cells.
Bibliography:L73
9426474
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0042-6822
1096-0341
DOI:10.1006/viro.1993.1309