Addition of prednisolone and heparin in patients with failed IVF/ICSI cycles: a preliminary report of a clinical trial

Abstract Through a non-randomized clinical trial, we examined the theoretical benefit of the coadministration of low molecular weight heparin (LMWH) and prednisolone on pregnancy outcomes in women with previously failed IVF/ICSI cycles. Fifteen women constituted the study group, and were compared wi...

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Bibliographic Details
Published inHuman fertility (Cambridge, England) Vol. 16; no. 3; pp. 207 - 210
Main Authors Siristatidis, Charalampos, Chrelias, Charalampos, Creatsa, Maria, Varounis, Christos, Vrachnis, Nikos, Iliodromiti, Zoe, Kassanos, Demetrios
Format Journal Article
LanguageEnglish
Published England Informa Healthcare 01.09.2013
Taylor & Francis
Subjects
Abortion, Spontaneous - prevention & control
Administration, Intravaginal
Administration, Oral
Adult
Anticoagulants - administration & dosage
Anticoagulants - pharmacology
Early Termination of Clinical Trials
Ectogenesis
Enoxaparin - administration & dosage
Enoxaparin - pharmacology
Female
Fertility Agents, Female - administration & dosage
Fertility Agents, Female - pharmacology
Fertilization in Vitro
glucocorticoids
Glucocorticoids - administration & dosage
Glucocorticoids - pharmacology
Greece - epidemiology
Humans
Infertility, Female - therapy
Live Birth
Low molecular weight heparin
Pilot Projects
prednisolone
Prednisolone - administration & dosage
Prednisolone - pharmacology
Pregnancy
Pregnancy Maintenance - drug effects
Pregnancy Rate
pregnancy rates
recurrent implantation failure
Sperm Injections, Intracytoplasmic
Greece
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Summary:Abstract Through a non-randomized clinical trial, we examined the theoretical benefit of the coadministration of low molecular weight heparin (LMWH) and prednisolone on pregnancy outcomes in women with previously failed IVF/ICSI cycles. Fifteen women constituted the study group, and were compared with 19 women receiving LMWH alone and another 18 women with no drugs. Our finding that the combination of the two drugs produced positive differences in terms of embryo quality, pregnancy and live birth rates points to the necessity for adequately powered randomized trials.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1464-7273
1742-8149
DOI:10.3109/14647273.2013.803608