Insulin resistance and cardiovascular risk factors in women with PCOS who have normal glucose tolerance test

• Published in: Gynecological endocrinology Vol. 29; no. 2; pp. 148 - 151
• Main Authors: Yildir, Ismail Cem, Kutluturk, Faruk, Tasliyurt, Turker, Yelken, Berna Murat, Acu, Berat, Beyhan, Murat, Erkorkmaz, Unal, Yilmaz, Abdulkerim
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.02.2013; Taylor & Francis
• Subjects: Adolescent; Adult; Blood Glucose - analysis; Body Mass Index; C-Reactive Protein - analysis; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Carotid Artery, Common - diagnostic imaging; Carotid Artery, Common - immunology; Carotid Artery, Common - pathology; Carotid Intima-Media Thickness; Carotid intimae-media thickness; Female; Ferritins - blood; glucose tolerance test; HOMA; Humans; Hyperandrogenism - etiology; Hyperinsulinism - etiology; Insulin Resistance; Overweight - complications; polycystic ovary syndrome; Polycystic Ovary Syndrome - complications; Polycystic Ovary Syndrome - immunology; Polycystic Ovary Syndrome - pathology; Polycystic Ovary Syndrome - physiopathology; Prospective Studies; Risk Factors; Turkey - epidemiology; Up-Regulation; Young Adult
• ISSN: 0951-3590; 1473-0766; 1473-0766
• DOI: 10.3109/09513590.2012.730573

Introduction: We aimed to determine the insulin resistance in women with PCOS patients who have normal oral glucose tolerance test (OGTT) and to evaluate cardiovascular risk by measuring C-reactive protein (CRP) and carotid intimae-media thickness (CIMT). Methods: A total of 34 patients and age and body mass matched 20 healthy control subjects were included to this prospective study. Both of patients and control groups were consisted of normal oral glucose tolerance test. Insulin resistance (IR) was estimated using HOMA-IR method. CRP, lipid and hormone levels were measured. CIMT was measured by Carotid Artery B-Mode ultrasonography. Results: There was no significant difference between patients and controls in BMI, and waist circumference, lipid, TSH, LH, FSH, estradiol, and prolactin levels. Serum insulin, testosterone, DHEAS, ferritin levels and HOMA values were significantly higher in patient group. We found that 64.7% (n = 22/34) patients with PCOS had insulin resistance. Both of CIMT and CRP levels were significantly higher in the PCOS patients had BMI over 25 kg/m2. CRP levels was significantly higher in the PCOS patients had waist circumference greater than 80 cm. Conclusion: We found insulin resistance in the women with PCOS even if OGTT was normal. Our data were similar to literature, the women with PCOS have increased risk of premature atherosclerosis and metabolic syndrome.