Interleukin-1 beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats

Interleukin (IL-1) is a cytokine which plays an important role in the modulation of the acute response in host defense. This cytokine is also increased in patients with Alzheimer's disease. In the present experiment systemic injection of IL-1 beta (7.5-50 micrograms/kg) decreased extracellular...

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Bibliographic Details
Published inBrain research Vol. 550; no. 2; p. 287
Main Authors Rada, P, Mark, G P, Vitek, M P, Mangano, R M, Blume, A J, Beer, B, Hoebel, B G
Format Journal Article
LanguageEnglish
Published Netherlands 07.06.1991
Subjects
Acetylcholine - metabolism
Animals
Choline - metabolism
Dialysis - methods
Extracellular Space - physiology
Hippocampus - drug effects
Hippocampus - physiology
Interleukin-1 - pharmacology
Kinetics
Male
Rats
Rats, Inbred Strains
Recombinant Proteins - pharmacology
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Summary:Interleukin (IL-1) is a cytokine which plays an important role in the modulation of the acute response in host defense. This cytokine is also increased in patients with Alzheimer's disease. In the present experiment systemic injection of IL-1 beta (7.5-50 micrograms/kg) decreased extracellular acetylcholine in the hippocampus. This effect could not be attributed entirely to general malaise since lithium chloride (130 mg/kg) had the opposite effect. Heat-inactivation of the cytokine eliminated the reduction of extracellular ACh. The results give further evidence of a relationship between the immune system and the central nervous system and suggest a possible relationship between IL-1 and cholinergic function or dysfunction in the hippocampus.
ISSN:0006-8993
DOI:10.1016/0006-8993(91)91330-4