Relationship between 2-deoxy-2-[18F]-fluoro-d-glucose uptake and clinicopathological factors in patients with diffuse large B-cell lymphoma

• Published in: Leukemia & lymphoma Vol. 55; no. 3; pp. 520 - 525
• Main Authors: Hirose, Yasumitsu, Suefuji, Hiroaki, Kaida, Hayato, Hayakawa, Masanobu, Hattori, Satoshi, Kurata, Seiji, Watanabe, Yuko, Kunou, Yukiko, Kawahara, Akihiko, Okamura, Takashi, Ohshima, Koichi, Kage, Masayoshi, Ishibashi, Masatoshi, Hayabuchi, Naofumi
• Format: Journal Article
• Language: English
• Published: United States Informa Healthcare 01.03.2014; Taylor & Francis
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological Transport; Child; Diffuse large B-cell lymphoma; FDG-PET; Female; Fluorodeoxyglucose F18 - metabolism; Glucose Transport Proteins, Facilitative - metabolism; glucose transporter; hexokinase-II; Humans; Immunohistochemistry; International Prognostic Index; Lymphoma, Large B-Cell, Diffuse - diagnosis; Lymphoma, Large B-Cell, Diffuse - metabolism; Male; Middle Aged; Neoplasm Staging; Positron-Emission Tomography; Retrospective Studies; Young Adult
• ISSN: 1042-8194; 1029-2403
• DOI: 10.3109/10428194.2013.807509

Abstract The aim of this study was to investigate correlations between the standardized uptake value of the biopsy site (BSUVmax) and levels of glucose transporter (GLUT)-1, GLUT-3 and hexokinase-II (HK-II), between BSUVmax and the Ki-67 proliferation index (MIB-1), and between BSUVmax and clinicopathological factors. Sixty-eight patients with diffuse large B-cell lymphoma (DLBCL) were included in this study. BSUVmax was significantly correlated with GLUT-1, GLUT-3 and the International Prognostic Index (IPI) (GLUT-1: r = 0.584, IPI: r = 0.363, p < 0.001; GLUT-3: r = 0.369, p = 0.009; IPI: r = 0.363, p = 0.004), but not with MIB-1 and HK-II. A statistically significant correlation was observed between GLUT-3 expression and each of IPI and gene expression profiling (GEP) (IPI: p = 0.0186; GEP: p = 0.0179). 2-Deoxy-2-[18F]-fluoro-d-glucose (FDG) uptake was significantly correlated with the levels of GLUT-1 and GLUT-3 and with IPI. The results indicated that GLUT-3 expression is related to GEP and IPI, and that BSUVmax and GLUT-3 may have a relationship with the prognosis of DLBCL.