The discriminative stimulus effect of MK-801 in ketamine-trained rats

MK-801 [(+)-5-methyl-10, 11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate] was assessed for its discriminative stimulus properties in rats trained to discriminate ketamine (7 mg/kg) from vehicle. MK-801 generalized to ketamine in a dose dependent manner with a maximum effect at 0.2 mg/kg, wh...

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Published inPharmacology, biochemistry and behavior Vol. 38; no. 1; pp. 211 - 213
Main Authors Benvenga, Mark J., Wing, Allison V., Del Vecchio, Robert A.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 1991
Elsevier Science
Subjects
Animals
Biological and medical sciences
Discrimination (Psychology) - drug effects
Dizocilpine Maleate - pharmacology
Dose-Response Relationship, Drug
Drug discrimination
Ketamine
Ketamine - pharmacology
Male
Medical sciences
Miscellaneous
MK-801
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
Phencyclidine
Rats
Rats, Inbred Strains
MK-801
Drug discrimination
Ketamine
Phencyclidine
Response generalization
Vertebrata
Intraperitoneal administration
Mammalia
Rat
Animal
Rodentia
Binding site
Antagonist
Mechanism of action
Stimulus discrimination
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Summary:MK-801 [(+)-5-methyl-10, 11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate] was assessed for its discriminative stimulus properties in rats trained to discriminate ketamine (7 mg/kg) from vehicle. MK-801 generalized to ketamine in a dose dependent manner with a maximum effect at 0.2 mg/kg, while ketamine generalized fully at 10 mg/kg. These results indicate that ketamine and MK-801 may share a common mechanism of action, which is related to the phencyclidine recognition site in the brain.
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ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(91)90613-7