Simultaneous use of multiple serologic tests in assessing clinical activity in systemic lupus erythematosus

Ten technics for quantifying and qualifying anti-DNA antibodies were correlated with manifestations of disease activity in sera from 27 patients with systemic lupus erythematosus (SLE) using both a simple and a stepwise regression. In the stepwise analysis, a panel consisting of four of these tests...

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Published inClinical immunology and immunopathology Vol. 51; no. 1; pp. 99 - 109
Main Authors Cronin, M.E., Leair, D.W., Jaronski, S., Lightfoot, R.W.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 01.04.1989
New York, NY Academic Press
Boston
Subjects
Autoantibodies - immunology
Biological and medical sciences
Complement Fixation Tests
DNA - immunology
Humans
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - immunology
Lupus Nephritis - immunology
Medical sciences
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Serologic Tests
Serology
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Summary:Ten technics for quantifying and qualifying anti-DNA antibodies were correlated with manifestations of disease activity in sera from 27 patients with systemic lupus erythematosus (SLE) using both a simple and a stepwise regression. In the stepwise analysis, a panel consisting of four of these tests provided maximal correlation ( r = 0.68) with clinical status. Low IgM anti-DNA was a significant correlate of nephritis in stepwise discriminant function analysis. Multivariate analysis can offer distinct advantages over simple correlation in understanding the role of serological abnormalities in disease expression in SLE.
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ISSN:0090-1229
1090-2341
DOI:10.1016/0090-1229(89)90210-9