Development of monoamine oxidase activity during postnatal development of the ground squirrel ( Citellus citellus)

• Published in: Comparative biochemistry and physiology. C, Comparative pharmacology Vol. 98; no. 2; pp. 377 - 380
• Main Authors: PETROVIC, V. M, JANIC-SIBALIC, V, CVIJIC, G
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier B.V 1991; Pergamon
• Subjects: Aging - metabolism; amine oxidase (flavin-containing); Animals; Animals, Newborn - growth & development; Animals, Newborn - metabolism; Biological and medical sciences; brain; Brain Stem - enzymology; Brain Stem - growth & development; Female; Fundamental and applied biological sciences. Psychology; Liver - enzymology; Liver - growth & development; Monoamine Oxidase - metabolism; Proteins - metabolism; Sciuridae - growth & development; Sciuridae - metabolism; Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Brain; Monoamine oxidase; Digestive system; Enzyme; Liver; Rodentia; Central nervous system; Postnatal development; Vertebrata; Mammalia; Enzymatic activity; Newborn animal; Hibernation
• ISSN: 0306-4492; 0742-8413
• DOI: 10.1016/0742-8413(91)90219-J

1. Monoamine oxidase (MAO) activity in the brain and peripheral tissues of newborn ground squirrel, as well as its evolution during postnatal development were studied. 2. Monoamine oxidase activity in the brain stem and liver, at the day of birth is significantly higher ( P < 0.01; P < 0.005) than in adults. 3. After that, enzyme activity decreases, but at the 25th day, e.g. at the day of the opening of the eyes, still remains significantly above the adult's value ( P < 0.01). 4. The results indicate some species specificity concerning the level and the evolution of cerebral and hepatic MAO activity as compared to the rats.