Ventilatory pattern and chest wall mechanics during ketamine anesthesia in humans

The effects of anesthetic doses of ketamine (iv bolus of 3 mg X kg-1 followed by a continuous infusion of 20 micrograms X kg-1 X min-1) on functional residual capacity (FRC) measured by the helium dilution method and on the breathing pattern recorded by a noninvasive method (NIM) based on chest wall...

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Published inAnesthesiology (Philadelphia) Vol. 65; no. 5; pp. 492 - 499
Main Authors MANKIKIAN, B, CANTINEAU, J. P, SARTENE, R, CLERGUE, F, VIARS, P
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott 01.11.1986
Subjects
Adult
Anesthesia
Anesthesia, Intravenous
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Applied sciences
Biological and medical sciences
Calibration
Exact sciences and technology
Functional Residual Capacity
General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation
Humans
Ketamine - pharmacology
Lung Volume Measurements - standards
Male
Medical sciences
Movement
Other techniques and industries
Respiration - drug effects
Respiratory Muscles - drug effects
Thorax - drug effects
Thorax - physiology
Tidal Volume
Human
Mechanic of breathing
General anesthesia
Intravenous administration
General anesthetic
Functional residual capacity
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Summary:The effects of anesthetic doses of ketamine (iv bolus of 3 mg X kg-1 followed by a continuous infusion of 20 micrograms X kg-1 X min-1) on functional residual capacity (FRC) measured by the helium dilution method and on the breathing pattern recorded by a noninvasive method (NIM) based on chest wall circumference changes were studied in 14 ASA P.S. I patients. Ketamine anesthesia was associated with: 1) the maintenance of FRC, minute ventilation, and tidal volume; 2) an increase in rib cage contribution to tidal breathing; and 3) an alteration of volume-motion relationships of the chest wall compartments. It is concluded that: 1) in contrast to volatile anesthetic agents, ketamine anesthesia has a sparing effect on intercostal muscle activity, which may explain the maintenance of FRC; and 2) changes in chest wall geometry and compliance induced by anesthetic agents must be taken into account for NIM to be valid.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0003-3022
1528-1175
DOI:10.1097/00000542-198611000-00007