The potential of miRNAs as biomarkers for multiple myeloma

Since the discovery of the link between miRNA and cancer, miRNAs have been investigated in virtually all tumors. Their ability to add a novel level of gene regulation and to target genes apparently not linked to each other has greatly intrigued researchers and physicians alike. In this review, the r...

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Bibliographic Details
Published inExpert review of molecular diagnostics Vol. 14; no. 8; p. 947
Main Authors Rocci, Alberto, Hofmeister, Craig C, Pichiorri, Flavia
Format Journal Article
LanguageEnglish
Published England 01.11.2014
Subjects
Biomarkers, Tumor
Gene Expression Regulation, Neoplastic
Humans
Intracellular Space
MicroRNAs - blood
MicroRNAs - genetics
MicroRNAs - metabolism
Multiple Myeloma - diagnosis
Multiple Myeloma - genetics
Multiple Myeloma - metabolism
Prognosis
multiple myeloma
miRNAs
staging system
biomarkers
circulating miRNAs
exosomes
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Summary:Since the discovery of the link between miRNA and cancer, miRNAs have been investigated in virtually all tumors. Their ability to add a novel level of gene regulation and to target genes apparently not linked to each other has greatly intrigued researchers and physicians alike. In this review, the role of miRNAs in multiple myeloma (MM) is summarized, with particular attention to their potential as biomarkers. The promising role of circulating miRNAs in diagnosis and risk stratification is also discussed, as well as preliminary results of miRNA-based therapeutic approaches. Finally, the critical issues in miRNA analysis in MM and ongoing strategies to solve them are discussed. The ability to standardize miRNA analysis procedures will permit the inclusion of miRNA evaluation alongside available stratification tools, paving the way for personalized medicine in MM.
ISSN:1744-8352
DOI:10.1586/14737159.2014.946906