Cytogenetic observations following thallium poisoning

Observations have been performed on peripheral blood lymphocytes from a patient having ingested 200 mg thallium sulfate, in order to evaluate the ability of the compound to produce cytogenetic damage in vivo in humans. Our results demonstrate that neither the yield of structural chromosome aberratio...

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Bibliographic Details
Published inJournal of toxicology and environmental health Vol. 50; no. 2; p. 97
Main Authors Hantson, P, Desoir, R, Léonard, E D, Crutzen-Fayt, M C, Léonard, A, Mahieu, P
Format Journal Article
LanguageEnglish
Published United States 07.02.1997
Subjects
Cell Nucleus - drug effects
Cells, Cultured
Chromosome Aberrations - genetics
Humans
Leukocytes - cytology
Leukocytes - drug effects
Male
Micronuclei, Chromosome-Defective - drug effects
Micronucleus Tests
Middle Aged
Rodenticides - poisoning
Sister Chromatid Exchange - drug effects
Thallium - poisoning
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Summary:Observations have been performed on peripheral blood lymphocytes from a patient having ingested 200 mg thallium sulfate, in order to evaluate the ability of the compound to produce cytogenetic damage in vivo in humans. Our results demonstrate that neither the yield of structural chromosome aberrations nor sister chromatid exchanges were significantly modified. The drastic increase of binucleated cells with micronuclei indicates that thallium sulfate has in common with many metallic compounds the ability to interfere with chromosome distribution.
ISSN:0098-4108
DOI:10.1080/009841097160500