Class effect of angiotensin-converting enzyme inhibitors on prevention of myocardial infarction

• Published in: The American journal of cardiology Vol. 94; no. 9; pp. 1171 - 1173
• Main Authors: Sauer, William H., Baer, Jefferson T., Berlin, Jesse A., Kimmel, Stephen E.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.11.2004; Elsevier; Elsevier Limited
• Subjects: Adrenergic beta-Antagonists - therapeutic use; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors - classification; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Antihypertensive Agents - classification; Antihypertensive Agents - therapeutic use; Benzazepines - therapeutic use; Biological and medical sciences; Calcium Channel Blockers - therapeutic use; Cardiology. Vascular system; Case-Control Studies; Comparative analysis; Coronary heart disease; Drug Therapy, Combination; Enzymes; Female; Heart; Heart attacks; Humans; Hypertension - prevention & control; Lisinopril - therapeutic use; Male; Medical sciences; Middle Aged; Multivariate Analysis; Myocardial Infarction - prevention & control; Myocarditis. Cardiomyopathies; Pharmaceuticals; Studies; Tetrahydroisoquinolines - therapeutic use; Treatment Outcome; United States; United States; Myocardial infarction; Prevention; Cardiovascular disease; Myocardial disease; Heart disease; ACE inhibitor
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2004.07.087

Angiotensin-converting enzyme (ACE) inhibitors differ in their affinity for tissue-bound ACE. It has been hypothesized that tissue ACE affinity might be responsible for some of the beneficial cardiovascular properties of ACE inhibitors. The present study examined this question and found no correlation between tissue ACE affinity and risk of first nonfatal myocardial infarction in patients who have hypertension.