Estradiol supplementation in intracytoplasmic sperm injection cycles with thin endometrium

• Published in: Gynecological endocrinology Vol. 29; no. 1; pp. 42 - 45
• Main Authors: Demir, Berfu, Dilbaz, Serdar, Cinar, Ozgur, Ozdegirmenci, Ozlem, Dede, Suat, Dundar, Betul, Goktolga, Umit
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.01.2013; Taylor & Francis
• Subjects: Abortion, Spontaneous - prevention & control; Adult; Chorionic Gonadotropin - administration & dosage; Databases, Factual; Embryo Implantation - drug effects; Endometrial thickness; Endometrium - drug effects; Endometrium - pathology; estradiol; Estradiol - administration & dosage; Estrogens - administration & dosage; Female; Fertilization in Vitro - methods; Humans; Infertility, Female - drug therapy; Infertility, Female - pathology; intracytoplasmic sperm injection; Luteal Phase - drug effects; luteal phase support; Pregnancy; Pregnancy Rate; Progesterone - administration & dosage; Retrospective Studies; Sperm Injections, Intracytoplasmic - methods
• ISSN: 0951-3590; 1473-0766
• DOI: 10.3109/09513590.2012.705381

Objective: To evaluate the efficacy of estradiol supplementation starting on the day of human chorionic gonadotrophin (hCG) in patients with thin endometrium in intracytoplasmic sperm injection (ICSI) cycles. Methods: A total of 117 consecutive patients with the endometrial thickness on the hCG day ≤8 mm were rewieved. Estradiol supplementation was given in 57 patients and the remaining 60 patients were accepted as control group. Estradiol supplemented (ES) group received estradiol hemihydrate 4 mg/day started on the day of hCG. Luteal phase was supported using the vaginal progesterone gel in both groups. Clinical pregnancy rate, implantation rate, miscarriage rate, endometrial thickness on the day of oocyte pick-up and on the day of embryo transferred were accepted as main outcome measures. Results: There were no statistical differences in terms of clinical pregnancy rate (28.1% vs. 23.3%), implantation rate (16% vs. 10.4%), miscarriage rate (21% vs. 31.6%), endometrial thickness on the oocyte pick-up day (8.5 ± 1.8 vs. 8.4 ± 1.4, mm) and embryo transferred day (9.6 ± 2.9 vs. 10.3 ± 2.4, mm) in the ES group vs. control group. Conclusion: Estradiol supplementation starting on the hCG day for the patients with thin endometrium does not provide any benefit on the pregnancy outcome in ICSI cycles.