A pilot clinical assessment of biphasic asymmetric pulsed field ablation catheter for pulmonary vein isolation
Pulsed field ablation (PFA) is a new treatment for atrial fibrillation (AF), and its selective ablation characteristics give it a significant advantage in treatment. In previous cellular and animal experiments, we have demonstrated that biphasic asymmetric pulses can be used to ablate myocardial tis...
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Published in | Frontiers in cardiovascular medicine Vol. 11; p. 1266195 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
07.02.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Pulsed field ablation (PFA) is a new treatment for atrial fibrillation (AF), and its selective ablation characteristics give it a significant advantage in treatment. In previous cellular and animal experiments, we have demonstrated that biphasic asymmetric pulses can be used to ablate myocardial tissue. However, small-scale clinical trials are needed to test whether this approach is safe and feasible before extensive clinical trials can be performed. Therefore, the purpose of this experiment is to determine the safety and feasibility of biphasic asymmetric pulses in patients with AF and is to lay the foundation for a larger clinical trial. Ablation was performed in 10 patients with AF using biphasic asymmetric pulses. Voltage mapping was performed before and after PFA operation to help us detect the change in the electrical voltage of the pulmonary veins (PV). 3-Dimensional mapping system showed continuous low potential in the ablation site, and pulmonary vein isolation (PVI) was achieved in all four PV of the patients. There were no recurrences, PV stenosis, or other serious adverse events during the 12 months follow-up. The results suggest that PFA using biphasic asymmetric waveforms for patients with AF is safe, durable, and effective and that a larger clinical trial could begin.
https://www.chictr.org.cn/, identifier, ChiCTR2100051894. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Damijan Miklavčič, University of Ljubljana, Slovenia Kelvin Chua, The Heart and Vascular Centre, Singapore These authors have contributed equally to this work Edited by: Christian Hendrik Heeger, University Heart Center Luebeck, Germany Mohamed A. Mostafa, Wake Forest Baptist Medical Center, United States |
ISSN: | 2297-055X 2297-055X |
DOI: | 10.3389/fcvm.2024.1266195 |