Overdose of Vinblastine in place of Vinorelbine during IGEV chemotherapy

• Published in: Immunopharmacology and immunotoxicology Vol. 34; no. 5; pp. 879 - 880
• Main Authors: Aversa, S. M. L., Zanon, S., Marino, D., Canova, F., Chiarion-Sileni, V., Jirillo, A.
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.10.2012; Taylor & Francis
• Subjects: Adult; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Case report; Chemical and Drug Induced Liver Injury - drug therapy; Colitis - chemically induced; Colitis - drug therapy; Female; Hodgkin Disease - drug therapy; Hodgkin's lymphoma; Humans; Medical Errors - adverse effects; Neutropenia - chemically induced; overdose of vinblastine; Pain - chemically induced; Pain - drug therapy; Prescription Drug Misuse; Thrombocytopenia - chemically induced; Vinblastine - administration & dosage; Vinblastine - adverse effects; Vinblastine - analogs & derivatives
• ISSN: 0892-3973; 1532-2513
• DOI: 10.3109/08923973.2012.663759

Any class of drugs is susceptible to errors, in case of antineoplastic agents the medication errors may cause severe and life-threatening toxicity due to very limited therapeutic index with toxic events even at therapeutic dosage, to complexity of regimens and the particular vulnerable population. We report herein a case of Vinblastine (VBL) accidental overdose, the cause of mistake, the toxic effect and the salvage therapy adopted in a young lady suffering of Hodgkin relapse during IGEV chemotherapy.