Genes important for otoneurological diagnostic purposes - current status and future prospects

This review focuses on the current knowledge of the genes responsible for non-syndromic hearing loss that can be useful for otoneurological diagnostic purposes. From among a large number of genes that have been associated with non-syndromic hearing impairment, we selected several best-known genes, i...

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Published inActa otorhino-laryngologica italica Vol. 38; no. 3; pp. 242 - 250
Main Authors Pawlak-Osiñska, K, Linkowska, K, Grzybowski, T
Format Journal Article
LanguageEnglish
Published Italy Pacini Editore Srl 01.06.2018
Subjects
Audiology
Diagnostic Techniques, Neurological - trends
Diagnostic Techniques, Otological - trends
Forecasting
Hearing Loss - diagnosis
Hearing Loss - genetics
Humans
Genetics
Tinnitus
Hearing impairment
Epilepsy
Vertigo
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Summary:This review focuses on the current knowledge of the genes responsible for non-syndromic hearing loss that can be useful for otoneurological diagnostic purposes. From among a large number of genes that have been associated with non-syndromic hearing impairment, we selected several best-known genes, including the COCH gene, GJB2, GJB6 and SLC26A4, and we describe their role and effects of mutations and prevalence of mutations in various populations. Next, we focus on genes associated with tinnitus. Important areas for further research include assessment of genes potentially involved in pathophysiology of tinnitus and vertigo, which have traditionally been considered as being of otological aetiology, while advances in neuroimaging techniques have increasingly shifted studies toward neurological correlations.
Bibliography:ObjectType-Article-2
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ISSN:1827-675X
0392-100X
1827-675X
DOI:10.14639/0392-100X-1692