Cost-effectiveness of vaccination against cervical cancer: A multi-regional analysis assessing the impact of vaccine characteristics and alternative vaccination scenarios

Summary Mathematical models provide valuable insights into the public health and economic impact of cervical cancer vaccination programmes. An in-depth economic analysis should explore the effects of different vaccine-related factors and vaccination scenarios (independent of screening practices) on...

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Bibliographic Details
Published inVaccine Vol. 26; pp. F29 - F45
Main Authors Suárez, Eugenio, Smith, Jennifer S, Bosch, F. Xavier, Nieminen, Pekka, Chen, Chien-Jen, Torvinen, Saku, Demarteau, Nadia, Standaert, Baudouin
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 15.09.2008
Subjects
Allergy and Immunology
Cohort Studies
Cost-effectiveness
Costs and Cost Analysis
Female
HPV vaccines
Humans
Models, Econometric
National Health Programs - economics
Uterine Cervical Neoplasms - economics
Uterine Cervical Neoplasms - prevention & control
Vaccination scenarios
Vaccine characteristics
HPV vaccines
Vaccine characteristics
Cost-effectiveness
Vaccination scenarios
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Summary:Summary Mathematical models provide valuable insights into the public health and economic impact of cervical cancer vaccination programmes. An in-depth economic analysis should explore the effects of different vaccine-related factors and vaccination scenarios (independent of screening practices) on health benefits and costs. In this analysis, a Markov cohort model was used to explore the impact of vaccine characteristics (e.g. cross-type protection and waning of immunity) and different vaccination scenarios (e.g. age at vaccination and multiple cohort strategies) on the cost-effectiveness results of cervical cancer vaccination programmes. The analysis was applied across different regions in the world (Chile, Finland, Ireland, Poland and Taiwan) to describe the influence of location-specific conditions. The results indicate that in all the different settings cervical cancer vaccination becomes more cost-effective with broader and sustained vaccine protection, with vaccination at younger ages, and with the inclusion of several cohorts. When other factors were varied, the cost-effectiveness of vaccination was most negatively impacted by increasing the discount rate applied to costs and health effects.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2008.05.069