Associations between plasma natriuretic peptide levels, symptoms, and left ventricular function in patients with chronic aortic regurgitation

• Published in: The American journal of cardiology Vol. 92; no. 6; pp. 755 - 758
• Main Authors: Gerber, Ivor L., Stewart, Ralph A.H., French, John K., Legget, Malcolm E., Greaves, Sally C., West, Teena M., Kerr, Andrew J., Richards, A.Mark, White, Harvey D.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.09.2003; Elsevier; Elsevier Limited
• Subjects: Adult; Aortic Valve Insufficiency - blood; Aortic Valve Insufficiency - complications; Aortic Valve Insufficiency - diagnostic imaging; Atrial Natriuretic Factor - blood; Biological and medical sciences; Cardiovascular disease; Cardiovascular system; Chronic Disease; Echocardiography; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Natriuretic Peptide, Brain - blood; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Peptides; Plasma; Predictive Value of Tests; Sensitivity and Specificity; Severity of Illness Index; Stroke Volume; Ventricular Dysfunction, Left - blood; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - etiology; Sonography; Human; Brain natriuretic peptide; Echocardiography; Pathophysiology; Biological marker; Cardiovascular disease; Atrial natriuretic peptide; Aortic regurgitation; Symptomatology; Cardiac valvular disease; Left ventricle performance; Aortic valve
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/S0002-9149(03)00849-X

In 40 patients with chronic moderate to severe aortic regurgitation, brain natriuretic peptide, N-brain natriuretic peptide, and atrial natriuretic peptide were higher in symptomatic patients compared with asymptomatic patients after adjustment for age, gender, and ejection fraction, but each natriuretic peptide correlated weakly with echocardiographic measures of left ventricular size and function. In patients with chronic aortic regurgitation, measurement of natriuretic peptide levels may provide information on left ventricular function in addition to echocardiography.