Association between Reproductive Span and Sarcopenia

• Published in: International journal of environmental research and public health Vol. 18; no. 1; p. 154
• Main Authors: Park, Eun Young, Han, Kyoung Hee, Chung, Tae Ha, Kim, Nam Yun, Lee, Ji Min, Choi, Seong Jin, Kim, Jong Koo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.12.2020; MDPI
• Subjects: Adolescent; Adult; Age; Aged; Alcohol; Body mass index; Chronic illnesses; Confidence intervals; Cross-Sectional Studies; Diabetes; Disease control; Fasting; Female; Glucose; Hormone replacement therapy; Humans; Hypertension; Laboratories; Menarche; Menopause; Metabolism; Middle Aged; Muscles; Musculoskeletal system; Nutrition; Nutrition Surveys; Odds Ratio; Population; Proteins; Regression analysis; Reproductive Health; Republic of Korea - epidemiology; Risk Factors; Sarcopenia; Sarcopenia - epidemiology; Sarcopenia - pathology; Skeletal muscle; Statistical analysis; Variables; Womens health; Young Adult; Republic of Korea; United States > US; menopause; reproductive span; menarche; sarcopenia
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph18010154

Sarcopenia is defined as an age-related loss of skeletal muscle and is associated with several health disorders. Causes of sarcopenia, which included physical inactivity, alcohol, dietary habits, and smoking, have been researched. The present study was undertaken to examine the association between reproductive span and sarcopenia in Korean women. Data obtained from 2008 to 2011 Korea National Health and Nutrition Examination Surveys (KNHANES) were analyzed. We defined sarcopenia based on the cut-off values of the Foundation for the National Institutes of Health (FNIH) sarcopenia project criteria: ASM/BMI < 0.512 for women. Reproductive span was defined as years from menarche to menopause, and we divided the 3970 study subjects into three groups by reproductive span tertile. Multivariate logistic regression analysis was used to determine adjusted ORs for the relation between reproductive span and sarcopenia. The prevalence of sarcopenia in the study was 17.7% (704 of 3970). Multiple logistic regression analysis was performed using weighted populations. After adjusting for covariates, reproductive span was found to be inversely associated with the risk of sarcopenia [Tertile 1 = 1 (reference); Tertile 2, odds ratio (OR) = 0.927, 95% confidence interval (CI) = 0.863-0.995; Tertile 3, OR = 0.854, 95% CI = 0.793-0.915].