Glucose-6-phosphate dehydrogenase - beyond the realm of red cell biology

Abstract Glucose-6-phosphate dehydrogenase (G6PD) is critical to the maintenance of NADPH pool and redox homeostasis. Conventionally, G6PD deficiency has been associated with hemolytic disorders. Most biochemical variants were identified and characterized at molecular level. Recently, a number of st...

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Bibliographic Details
Published inFree radical research Vol. 48; no. 9; pp. 1028 - 1048
Main Authors Ho, H.-Y., Cheng, M.-L., Chiu, D. T.-Y.
Format Journal Article
LanguageEnglish
Published England Informa Healthcare 01.09.2014
Taylor & Francis
Subjects
antioxidant
G6PD
Glucosephosphate Dehydrogenase - physiology
Glucosephosphate Dehydrogenase Deficiency - genetics
Glucosephosphate Dehydrogenase Deficiency - physiopathology
Humans
NADPH
reactive oxygen species
NADPH
G6PD
antioxidant
reactive oxygen species
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Summary:Abstract Glucose-6-phosphate dehydrogenase (G6PD) is critical to the maintenance of NADPH pool and redox homeostasis. Conventionally, G6PD deficiency has been associated with hemolytic disorders. Most biochemical variants were identified and characterized at molecular level. Recently, a number of studies have shone light on the roles of G6PD in aspects of physiology other than erythrocytic pathophysiology. G6PD deficiency alters the redox homeostasis, and affects dysfunctional cell growth and signaling, anomalous embryonic development, and altered susceptibility to infection. The present article gives a brief review of basic science and clinical findings about G6PD, and covers the latest development in the field. Moreover, how G6PD status alters the susceptibility of the affected individuals to certain degenerative diseases is also discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1071-5762
1029-2470
DOI:10.3109/10715762.2014.913788