The Drosophila genome

The past year has been a spectacular one for Drosophila research. The sequencing and annotation of the Drosophila melanogaster genome has allowed a comprehensive analysis of the first three eukaryotes to be sequenced—yeast, worm and fly—including an analysis of the fly's influences as a model f...

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Bibliographic Details
Published inCurrent Opinion in Genetics & Development Vol. 10; no. 6; pp. 612 - 616
Main Author Celniker, Susan E
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2000
Subjects
Animals
comparative genomics
disease
Drosophila
Drosophila melanogaster
Drosophila melanogaster - genetics
gene annotation
Gene Expression
Genes, Insect
Genetic Predisposition to Disease
Genome
genome shotgun assembly
homologous recombination
Humans
Insect Proteins - genetics
Insect Proteins - physiology
microarrays
Recombination, Genetic
genome
disease
homologous recombination
genome shotgun assembly
Drosophila
gene annotation
comparative genomics
microarrays
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Summary:The past year has been a spectacular one for Drosophila research. The sequencing and annotation of the Drosophila melanogaster genome has allowed a comprehensive analysis of the first three eukaryotes to be sequenced—yeast, worm and fly—including an analysis of the fly's influences as a model for the study of human disease. This year has also seen the initiation of a full-length cDNA sequencing project and the first analysis of Drosophila development using high-density DNA microarrays containing several thousand Drosophila genes. For the first time homologous recombination has been demonstrated in flies and targeted gene disruptions may not be far off.
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ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(00)00140-4