Spinal cord transection induced c-Fos protein in the rat motor cortex
Spinal cord transection at the middle thoracic level induced the expression of c-Fos protein in the rat motor cortex detected with the immunohistochemical study. At 1 h after transection, maximal expression of c-Fos was seen in the frontal cortex and hindlimb area of the cortex. c-Fos-like immunorea...
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Published in | Brain research Vol. 792; no. 1; pp. 164 - 167 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
London
Elsevier B.V
04.05.1998
Amsterdam Elsevier New York, NY |
Subjects | |
Online Access | Get full text |
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Summary: | Spinal cord transection at the middle thoracic level induced the expression of c-Fos protein in the rat motor cortex detected with the immunohistochemical study. At 1 h after transection, maximal expression of c-Fos was seen in the frontal cortex and hindlimb area of the cortex. c-Fos-like immunoreactive neurons were recognized in the second to sixth layers of these cortices, although the axotomized neurons were located only in the fifth layer of these cortices. A significant difference of c-Fos-like protein expression was observed between the spinal transected group and the sham operated group 1 h after the operation. These results indicate that each layer of the motor cortical column is activated and that there is a correlation between alteration of the neuronal network and functional plasticity. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0006-8993 1872-6240 |
DOI: | 10.1016/S0006-8993(98)00213-3 |