Healthy sibling donor anxiety and pain during bone marrow or peripheral blood stem cell harvesting for allogeneic transplantation : Results of a randomised study

• Published in: Bone marrow transplantation (Basingstoke) Vol. 29; no. 2; pp. 145 - 149
• Main Authors: FORTANIER, C, KUENTZ, M, SUTTON, L, MILPIED, N, MICHALET, M, MACQUART-MOULIN, G, FAUCHER, C, LE CORROLLER, A-G, MOATTI, J-P, BLAISE, D
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 2002
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anxiety; Anxiety - etiology; Biological and medical sciences; Blood Cells; Bone marrow; Bone Marrow Cells; Bone marrow transplantation; Bone marrow, stem cells transplantation. Graft versus host reaction; Collection; Female; Granulocyte colony-stimulating factor; Granulocyte Colony-Stimulating Factor - adverse effects; Hematopoietic stem cells; Humans; Male; Medical sciences; Pain; Pain - etiology; Peripheral blood; Psychological factors; Siblings; Stem cell transplantation; Stem Cell Transplantation - methods; Stem cells; Surveys and Questionnaires; Tissue and Organ Harvesting - adverse effects; Tissue and Organ Harvesting - psychology; Tissue Donors - psychology; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation; Transplantation, Homologous; Human; Stem cell; Cytokine; Hematopoietic cell; Homograft; Well being; Psychometrics; Blood; Mobilization; Granulocyte colony stimulating factor; Pain; Donor; Polypeptide; Bone marrow; Graft; Anxiety; Gathering
• ISSN: 0268-3369; 1476-5365
• DOI: 10.1038/sj.bmt.1703338

This study reports the first comparison of healthy donor subjective well-being during two alternative procedures of hematopoietic stem cells harvesting for allogeneic transplantation. Among the 105 donors included between September 1996 and October 1998 in the SFGM French randomised trial aiming to compare allogeneic bone marrow (BM) transplantation and blood cell (BC) transplantation, 64 donors (33 in BC and 31 in BM groups) were relevant for the analysis. They had received a set of self-administered questionnaires to complete during the collection process, aiming to measure anxiety (assessed using the Spielberger's State-Trait Anxiety Inventory) and pain induced by the procedure (evaluated using a visual analogical scale). Results showed that no harvest procedure is free from pain even if none was more painful than the other. Levels of anxiety before the collection procedure were high in both groups and significantly so for BC donors. Although BC collection induces at least similar levels of pain and anxiety as does BM collection, they were of a different kind, and the short-term impact of G-CSF stimulation on the well-being of BC donors has to be taken into account in improving quality of care in the allogeneic setting.