Comparison of tamsulosin and silodosin in the management of acute urinary retention secondary to benign prostatic hyperplasia in patients planned for trial without catheter. A prospective randomized study

• Published in: Central European journal of urology Vol. 70; no. 3; pp. 259 - 263
• Main Authors: Patil, Siddangouda B, Ranka, Kshitiz, Kundargi, Vinay S, Guru, Nilesh
• Format: Journal Article
• Language: English
• Published: Poland Polish Urological Association 01.01.2017
• Subjects: Bladder; Intubation; Original Paper; Patients; Prostate; Prostate cancer; Retention; Urinary tract infections; Urine; Urogenital system; Urology; trial without catheter; tamsulosin; silodosin; benign prostatic hyperplasia; acute urinary retention
• ISSN: 2080-4806; 2080-4873; 2080-4873
• DOI: 10.5173/ceju.2017.1313

We present a prospective randomized study to compare the efficacy of tamsulosin and silodosin in patients suffering from acute urinary retention caused by benign prostatic hyperplasia, planned for trial without catheter. Patients with acute urinary retention secondary to benign prostatic hyperplasia (total 160) were catheterized and randomized into two groups: Group A: tamsulosin 0.4 mg (80 patients) and Group B: silodosin 8 mg (80 patients). After three days, the catheter was removed, and patients were put on trial without catheter. Patients with a successful trial without catheter were followed up after two weeks and one month, taking into account the international prostate symptom score (IPSS), post void residual volume (PVR), and peak flow rate (PFR). Statistical analysis of the data was performed. Both group A (tamsulosin) and group B (silodosin) had similar results of trial without catheter (group A: 67.50%, group: B 60%). In follow up, three patients in group A and four patients in group B had retention of urine, requiring recatheterization. These patients were withdrawn from the study. No significant differences were present between group A and group B patients in regard with IPSS, PVR and PFR measured at the time of successful trial without catheter and during follow up at two weeks and one month. Efficacy for trial without catheter of tamsulosin was slightly higher than silodosin, but comparable. No statistical difference between tamsulosin & silodosin treated groups were found in regard with IPSS, PVR and PFR.