High-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of polycystic ovary syndrome in Indian adolescent women with polycystic ovary syndrome (PCOS)

• Published in: Gynecological endocrinology Vol. 30; no. 11; pp. 781 - 784
• Main Authors: Ganie, Mohd Ashraf, Hassan, Saqib, Nisar, Sobia, Shamas, Nasir, Rashid, Aafia, Ahmed, Ishfaq, Douhat, Syed, Mudassar, Syed, Jan, Vicar M., Rashid, Fouzia
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.11.2014; Taylor & Francis
• Subjects: Adolescent; Adult; Blood Glucose - metabolism; Body Mass Index; C-Reactive Protein - metabolism; Cardiovascular Diseases - blood; Cardiovascular Diseases - etiology; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - etiology; Female; Ferriman-Gallwey score; Follicle Stimulating Hormone - blood; Glucose Tolerance Test; HOMA-IR; hs C-reactive protein; Humans; India; Insulin - blood; insulin resistance; Insulin Resistance - physiology; Lipids - blood; Luteinizing Hormone - blood; obesity; Obesity - blood; polycystic ovary syndrome; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - complications; Risk Factors; testosterone; Testosterone - blood; Thyroid Hormones - blood; Young Adult; India; Body mass index; HOMA-IR; hs C-reactive protein; testosterone; insulin resistance; Ferriman–Gallwey score; obesity; polycystic ovary syndrome
• ISSN: 0951-3590; 1473-0766; 1473-0766
• DOI: 10.3109/09513590.2014.924099

Abstract C-reactive protein (CRP) is a risk marker for type 2 diabetes mellitus and cardiovascular diseases. In polycystic ovary syndrome (PCOS), limited data are available on high-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of PCOS especially in Indian women. The objective was to determine serum hs-CRP concentration in adolescent women with and without PCOS and to assess possible correlations of serum hs-CRP levels with components of PCOS in Indian women. One hundred and sixty women with PCOS and sixty non-PCOS women having normal menstrual cycles were included. Clinical assessment included anthropometry, Ferriman-Gallwey (FG) score and blood pressure (BP) measurement. Laboratory evaluation included estimation of T4, TSH, LH, FSH, total testosterone, prolactin, cortisol, 17OHP, hs-CRP, lipid profile, and insulin, and glucose after 2-h oral glucose tolerance test. Homeostasis Model Assessment Insulin resistance index (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) and glucose intolerance was calculated. FG score, LH, FSH, total Testosterone, HOMA-IR and QUICKI were significantly different among women with or without PCOS (p < 0.01). Although hs-CRP levels showed a higher trend in women having PCOS, there was no significant difference between the groups (p > 0.05). A significant and positive correlation was found between hs-CRP and body mass index (BMI) (r = 0.308, p < 0.01) among PCOS group. The results in Indian adolescent women suggest that hs-CRP levels may not per se be associated with PCOS, rather can be related to fat mass in this subset of subjects. Chinese abstract C反应蛋白（CRP）是2型糖尿病和心血管疾病的危险因素。对于多囊卵巢综合征（PCOS），尤其是印度女性，在高敏C反应蛋白（hs-CRP）水平及其与PCOS的各项组分的关系方面，可查到的数据很有限。本研究的目的是监测患或不患PCOS的青春期女性的血清hs-CRP浓度，评估印度女性的血清hs-CRP浓度与PCOS指标间可能的相关性。160名PCOS患者和60名有正常月经周期的非PCOS女性参与了本试验。临床评价包括人体测量，Ferriman-Gallwey（FG）评分和血压（BP）测量。实验室测定指标包括T4，TSH， LH,，FSH，总睾酮，催乳素，皮质醇，17-OHP，hs-CRP，血脂，胰岛素的测量和2h口服葡萄糖耐量试验。同时测量稳态模式评估胰岛素抵抗指数（HOMA-IR），定量胰岛素敏感性检测指数（QUICKI）以及葡萄糖耐量。PCOS患者与正常女性的FG得分，LH,，FSH，HOMA-IR，QUICKI存在显著不同（p<0.01），尽管PCOS患者的hs-CRP水平有增高的趋势，但两组并无显著差别（p>0.05)。在PCOS组还发现hs-CRP与体重指数（BMI）有显著正相关（r=0.308, p<0.01）。该结果表明，hs-CRP水平与PCOS也许无关联性，而可能与该课题中的子项目即体重相关。