Pathophysiology of fibroid disease: angiogenesis and regulation of smooth muscle proliferation

Uterine fibroids are the most common tumours presenting in women. The pathophysiology of fibroids is poorly understood, but disordered angiogenesis and altered smooth muscle cell proliferation are believed to play a role. In this review, current knowledge of both of these processes will be summarize...

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Published inBest practice & research. Clinical obstetrics & gynaecology Vol. 22; no. 4; pp. 603 - 614
Main Authors Fleischer, Roni, Weston, Gareth C., MBBS, MPH, PhD, FRANZCOG, Vollenhoven, Beverley J., MBBS, PhD, FRANZCOG, CREI, Rogers, Peter A.W., PhD
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.08.2008
Subjects
angiogenesis
blood vessels
Cell Proliferation
Estrogens - physiology
Female
Growth Substances - physiology
Humans
Leiomyoma - blood supply
Leiomyoma - pathology
Leiomyoma - physiopathology
leiomyomas
Muscle, Smooth - pathology
Neovascularization, Pathologic - pathology
Obstetrics and Gynecology
Progesterone - physiology
smooth muscle cell proliferation
uterine fibroid
Uterine Neoplasms - blood supply
Uterine Neoplasms - pathology
Uterine Neoplasms - physiopathology
smooth muscle cell proliferation
blood vessels
uterine fibroid
leiomyomas
angiogenesis
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Summary:Uterine fibroids are the most common tumours presenting in women. The pathophysiology of fibroids is poorly understood, but disordered angiogenesis and altered smooth muscle cell proliferation are believed to play a role. In this review, current knowledge of both of these processes will be summarized. Differences between ‘normal’ adjacent myometrium and fibroid tumours within the same uterus are outlined. Exploiting these differences represents one of the best opportunities for the development of medical treatments that target fibroid tissue selectively.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1521-6934
1532-1932
DOI:10.1016/j.bpobgyn.2008.01.005