Extracellular Vesicles Obtained From Lung Adenocarcinoma Cells Cultured Under Intermittent Hypoxia Induce M2 Macrophage Polarization via miR-20a-5p Delivery

These findings indicate that EVs obtained from lung adenocarcinoma cells cultured under IH deliver miR-20a-5p to promote M2 macrophage polarization by targeting PTEN.

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Bibliographic Details
Published inTechnology in cancer research & treatment Vol. 23; p. 15330338231219415
Main Authors Liu, Yuanling, Lu, Minzhen, Liu, Feng, Xu, Gang, Feng, Congrui, Chen, Yuluo, Cai, Danyan, Sun, Huake, Zeng, Yanjun, Xie, Jian, Ma, Wei, Gao, Xinglin
Format Journal Article
LanguageEnglish
Published United States SAGE Publications 01.01.2024
SAGE Publishing
Subjects
Adenocarcinoma of Lung - genetics
Extracellular Vesicles
Humans
Hypoxia
Macrophages
MicroRNAs - genetics
Original
lung cancer
obstructive sleep apnea
macrophage
microRNA
extracellular vesicle
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Summary:These findings indicate that EVs obtained from lung adenocarcinoma cells cultured under IH deliver miR-20a-5p to promote M2 macrophage polarization by targeting PTEN.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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These authors have contributed equally to this work.
ISSN:1533-0346
1533-0338
DOI:10.1177/15330338231219415