Comparison of clinical benefits of clopidogrel therapy in patients with acute coronary syndromes taking atorvastatin versus other statin therapies

• Published in: The American journal of cardiology Vol. 92; no. 3; pp. 285 - 288
• Main Authors: Wienbergen, Harm, Gitt, Anselm Kai, Schiele, Rudolf, Juenger, Claus, Heer, Tobias, Meisenzahl, Christina, Limbourg, Peter, Bossaller, Claus, Senges, Jochen
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.2003; Elsevier; Elsevier Limited
• Subjects: Acute Disease; Aged; Antianginal agents. Coronary vasodilator agents; Atorvastatin; Biological and medical sciences; Cardiovascular disease; Cardiovascular system; Clopidogrel; Comorbidity; Comparative analysis; Coronary Disease - drug therapy; Coronary Disease - mortality; Drug Interactions; Drug therapy; Drug Utilization - statistics & numerical data; Female; Germany - epidemiology; Heptanoic Acids - therapeutic use; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Male; Medical sciences; Middle Aged; Patients; Pharmacology. Drug treatments; Prospective Studies; Pyrroles - therapeutic use; Registries - statistics & numerical data; Stroke - epidemiology; Survival Analysis; Syndrome; Ticlopidine - analogs & derivatives; Ticlopidine - therapeutic use; Treatment Outcome; Human; Chemotherapy; Treatment; Atorvastatin; Cardiovascular disease; Clopidogrel; Evolution; Statin derivative; Coronary heart disease
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/S0002-9149(03)00626-X

In clinical practice, we found no significant difference between atorvastatin therapy or other statin therapies in the clinical outcomes of patients with acute coronary syndromes receiving clopidogrel therapy. In patients receiving atorvastatin therapy, clopidogrel therapy was associated with a significant decrease in mortality and stroke during univariate analysis and a moderate trend of reduced mortality and stroke without statistical significance in the multivariate analysis.