Effect of cationic ionophore monensin on the lipid composition and fluidity of rat epididymal spermatozoal membrane

• Published in: Drug and chemical toxicology (New York, N.Y. 1978) Vol. 36; no. 1; pp. 79 - 87
• Main Authors: Sharma, Pinky, Kanwar, Shailender Singh, Sanyal, S. N.
• Format: Journal Article
• Language: English
• Published: United States Informa Healthcare 01.01.2013; Taylor & Francis
• Subjects: Animals; Calcium - metabolism; Cholesterol - analysis; dye binding; Epididymis - drug effects; fluorescence anisotropy; Gangliosides - analysis; lipid composition; Male; Membrane Fluidity - drug effects; Membrane Lipids - analysis; Monensin; Monensin - pharmacology; rat epididymis; Rats; Rats, Wistar; Sodium Ionophores - pharmacology; Spermatozoa - drug effects; spermatozoal membrane

The present study was aimed at exploring the effect of monensin, an antibiotic carboxylic polyether ionophore specific for Na+, on the structural, chemical, and physiological changes of the epididymal sperm of Wistar rats. Animals received monensin at the dose of 3.5 mg/kg body weight daily orally f...