Lack of Association between Cytokine Genetic Polymorphisms in Takayasu's Arteritis in Mexican Patients

• Published in: International journal of environmental research and public health Vol. 16; no. 23; p. 4863
• Main Authors: Soto, María Elena, Huesca-Gómez, Claudia, Torres-Paz, Yazmín, Fuentevilla-Álvarez, Giovanny, Gamboa, Ricardo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.12.2019; MDPI
• Subjects: Adolescent; Adult; Aged; Arteritis; Blood pressure; Body mass; Body mass index; Body size; Cardiology; Cardiovascular disease; Cardiovascular diseases; Case-Control Studies; CD4 antigen; CD8 antigen; Child; Coronary artery disease; Coronary vessels; Cytokines; Cytokines - genetics; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Female; Gene Frequency; Genes; Genotype; Genotype & phenotype; Haplotypes; Heart diseases; Humans; Hypertension; Inflammation; Interferon; Interleukin 10; Lipids; Lymphocytes; Lymphocytes T; Macrophages; Male; Mexico; Middle Aged; Natural killer cells; Polymorphism, Genetic; Pulmonary arteries; Rheumatology; Takayasu Arteritis - genetics; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Vein & artery diseases; Veins & arteries; Young Adult; γ-Interferon; Mexico; United States > US; Mexican population; Takayasu′s arteritis; cytokines; polymorphisms
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph16234863

: To investigate the relation between polymorphisms in the interleukin 10 ( )- , tumor necrosis factor ( -α, transforming growth factor ( β and interferon ( genes and Takayasu's arteritis in the Mexican population. : A case-control study was performed to investigate the associations of , , and polymorphisms in a sample of 52 Takayasu's arteritis patients, diagnosed according to the criteria of the American College of Rheumatology and EULAR PRINTO criteria when the patients were under 18 years of age; 60 clinically healthy unrelated Mexican individuals by the 5' exonuclease TaqMan polymerase chain reaction. Polymorphic haplotypes were constructed after linkage disequilibrium analysis. Significant differences were not found in the distribution for genotype and allele frequencies of the polymorphisms studied between healthy controls and Takayasu´s arteritis patients. Likewise, significant associations were not detected in the haplotype analysis with the different genes studied. : These findings suggest that the polymorphisms in , , and might not contribute to the susceptibility of Takayasu´s arteritis in the Mexican population.