Brazilian Green Propolis Improves Antioxidant Function in Patients with Type 2 Diabetes Mellitus

• Published in: International journal of environmental research and public health Vol. 13; no. 5; p. 498
• Main Authors: Zhao, Liting, Pu, Lingling, Wei, Jingyu, Li, Jinghua, Wu, Jianquan, Xin, Zhonghao, Gao, Weina, Guo, Changjiang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2016; MDPI
• Subjects: Acids; Adiponectin; Adiponectin - blood; Adult; Aged; Aldehyde reductase; Antioxidants; Bioengineering; Biological properties; Blood Glucose - analysis; Brazil; Carbonyl compounds; Carbonyls; Cytokines; Cytokines - blood; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Disease; Drug dosages; Enzymes; Female; Glucose; Glucose metabolism; Glutathione - blood; Glycated Hemoglobin A - analysis; Hemoglobin; Humans; IL-1β; Insulin; Insulin - blood; Insulin resistance; Interleukin 6; Intervention; L-Lactate dehydrogenase; Laboratories; Lactate dehydrogenase; Lactic acid; Male; Metabolism; Middle Aged; Polyphenols; Polyphenols - blood; Propolis; Propolis - pharmacology; Propolis - therapeutic use; Reductases; Statistical analysis; Tumor necrosis factor-α; United States > US; China; antioxidant function; type 2 diabetes mellitus; Brazilian green propolis
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph13050498

Propolis contains a variety of bioactive components and possesses many biological properties. This study was designed to evaluate potential effects of Brazilian green propolis on glucose metabolism and antioxidant function in patients with type 2 diabetes mellitus (T2DM). In the 18-week randomized controlled study, enrolled patients with T2DM were randomly assigned to Brazilian green propolis group (900 mg/day) (n = 32) and control group (n = 33). At the end of the study, no significant difference was found in serum glucose, glycosylated hemoglobin, insulin, aldose reductase or adiponectin between the two groups. However, serum GSH and total polyphenols were significantly increased, and serum carbonyls and lactate dehydrogenase activity were significantly reduced in the Brazilian green propolis group. Serum TNF-α was significantly decreased, whereas serum IL-1β and IL-6 were significantly increased in the Brazilian green propolis group. It is concluded that Brazilian green propolis is effective in improving antioxidant function in T2DM patients.