Biology and therapeutic potential of interleukin-10

The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from over-exuberant responses to pathogens and microbiota, while playing important roles in other settings as sterile wound healing, autoimmunity, cancer, and homeostasis. Here we discuss our current understanding o...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of experimental medicine Vol. 217; no. 1
Main Authors Saraiva, Margarida, Vieira, Paulo, O’Garra, Anne
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 06.01.2020
SeriesCytokines Focus
Subjects
Animals
Autoimmunity - immunology
Cytokines - immunology
Cytokines - metabolism
Humans
Immunology
Inflammation - immunology
Inflammation - metabolism
Interleukin-10 - immunology
Interleukin-10 - metabolism
Life Sciences
Neoplasms - immunology
Neoplasms - metabolism
Reviews
Online AccessGet full text

Cover

More Information
Summary:The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from over-exuberant responses to pathogens and microbiota, while playing important roles in other settings as sterile wound healing, autoimmunity, cancer, and homeostasis. Here we discuss our current understanding of the regulation of IL-10 production and of the molecular pathways associated with IL-10 responses. In addition to IL-10’s classic inhibitory effects on myeloid cells, we also describe the nonclassic roles attributed to this pleiotropic cytokine, including how IL-10 regulates basic processes of neural and adipose cells and how it promotes CD8 T cell activation, as well as epithelial repair. We further discuss its therapeutic potential in the context of different diseases and the outstanding questions that may help develop an effective application of IL-10 in diverse clinical settings.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0022-1007
1540-9538
1540-9538
DOI:10.1084/jem.20190418