Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration

• Published in: Brain (London, England : 1878) Vol. 142; no. 11; pp. 3621 - 3635
• Main Authors: Bejanin, Alexandre, Murray, Melissa E, Martin, Peter, Botha, Hugo, Tosakulwong, Nirubol, Schwarz, Christopher G, Senjem, Matthew L, Chételat, Gael, Kantarci, Kejal, Jack, Clifford R, Boeve, Bradley F, Knopman, David S, Petersen, Ronald C, Giannini, Caterina, Parisi, Joseph E, Dickson, Dennis W, Whitwell, Jennifer L, Josephs, Keith A
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.11.2019
• Subjects: Aged; Aged, 80 and over; Amyloid beta-Peptides - metabolism; Brain - pathology; Cohort Studies; Disease Progression; DNA-Binding Proteins - metabolism; Female; Frontotemporal Dementia - diagnostic imaging; Frontotemporal Dementia - metabolism; Frontotemporal Dementia - pathology; Gray Matter - pathology; Humans; Life Sciences; Magnetic Resonance Imaging; Male; Neurodegenerative Diseases - diagnostic imaging; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Original; Prospective Studies; tau Proteins - metabolism; Temporal Lobe - metabolism; Temporal Lobe - pathology; tau; radiological-pathological study; TDP-43; neuropathology; β-amyloid
• ISSN: 0006-8950; 1460-2156; 1460-2156
• DOI: 10.1093/brain/awz277

The specific effect of TDP-43 pathology on grey matter volume in individuals without frontotemporal lobar degeneration is unclear. Bejanin et al. reveal a major and independent contribution of TDP-43 to neurodegeneration and shed light on the regional distribution of TDP-43-related atrophy in older adults.