Electrochemical detection of circulating tumor cells: A mini review

• Published in: Electrochemistry communications Vol. 124; p. 106949
• Main Authors: Li, Xiao-Rui, Zhou, Yi-Ge
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.03.2021; Elsevier
• Subjects: Circulating tumor cells; Electrochemical cytosensor; Nanoparticle impact electrochemistry; Single cell analysis; Electrochemical cytosensor; Nanoparticle impact electrochemistry; Circulating tumor cells; Single cell analysis
• ISSN: 1388-2481; 1873-1902
• DOI: 10.1016/j.elecom.2021.106949

•Electrochemical detection of CTCs is reviewed based on three different analysis principles.•Electrochemical analysis of single CTCs is summarized with a special focus of the single particle impact method.•A short perspective is given regarding the impact electrochemistry based single CTC analysis. Circulating tumor cell (CTC) is an important biomarker for early diagnosis of cancer. Among a number of greatly advanced strategies, electrochemical CTC sensors show advantages such as simplicity, fast response, low cost and the capability for miniaturization. In this mini review, we present recent development of the electrochemical cytosensors primarily in the past 5 years based on different detection principles. In the conclusion, we point out the current challenges of the electrochemical CTC detection platform and highlight the importance of single CTC detection. An outlook particularly on the impact method for single CTC analysis is also given.