The effect of polymeric additives on the solubilisation of a poorly-soluble drug in micellar solutions of Pluronic F127

• Published in: International journal of pharmaceutics Vol. 409; no. 1; pp. 206 - 208
• Main Authors: Oliveira, Cristiane P., Vasconcellos, Luiz C.G., Ribeiro, Maria Elenir N.P., Ricardo, Nágila M.P.S., Souza, Ticiane V. de P., Costa, Flávia de M.L.L., Chaibundit, Chiraphon, Yeates, Stephen G., Attwood, David
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 16.05.2011; Elsevier
• Subjects: additives; Biological and medical sciences; drugs; Excipients - chemistry; General pharmacology; griseofulvin; Griseofulvin - administration & dosage; Griseofulvin - chemistry; Medical sciences; Micelles; PEG; Pharmaceutical Solutions; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Pluronic F127; Poloxamer - chemistry; polyethylene glycol; Polyethylene Glycols - chemistry; Polymers - chemistry; Povidone - chemistry; PVP; Solubilisation; Solubility; solubilization; Pluronic F127; PEG; PVP; Solubilisation; Micelles; Drug; Pharmaceutical technology; Vehicle(excipient); Micelle; Laxative; Ethylene oxide copolymer; Solubilization; Ethylene oxide polymer; Triblock copolymer; Cyclic ether polymer; Pyrrolidone(vinyl) polymer; Cyclic ether copolymer; Poloxamer; Propylene oxide copolymer; Micellar solution
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2011.02.025

The solubilisation of griseofulvin in 1 wt% aqueous micellar solutions of Pluronic F127 at 37 °C has been modified by adding polyethylene glycol PEG 35000 or poly(vinylpyrrolidone) PVP K30. The solubilisation capacity expressed in terms of unit weight of F127 is increased by the addition of 0.5 wt% PEG 35000 to a value approaching double that of a 2.5 wt% solution of F127 alone, but there is no advantage in adding 0.5 wt% PVP K30.