Early postnatal development of peptide hydrolysis in chicks and guinea pigs

• Published in: Comparative biochemistry and physiology. A, Comparative physiology Vol. 99; no. 3; pp. 441 - 447
• Main Author: Tarvid, I.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier B.V 1991; Elsevier
• Subjects: Animals; Animals, Newborn - growth & development; Animals, Newborn - metabolism; Biological and medical sciences; Carboxypeptidases - metabolism; Carboxypeptidases A; Cell Membrane - enzymology; Chickens; Dipeptidases - metabolism; Fundamental and applied biological sciences. Psychology; General aspects; glycylleucine dipeptidase; Guinea Pigs; Hydrolysis; Intestine, Small - enzymology; Male; Pancreas - enzymology; Peptides - metabolism; Vertebrates: digestive system; Peptides; Digestive system; Growth; Enzyme; Rodentia; Gut; Postnatal development; Hydrolysis; Vertebrata; Mammalia; Guinea pig; Enzymatic activity; Carboxypeptidase A; Chicken; Aves; Pancreas
• ISSN: 0300-9629
• DOI: 10.1016/0300-9629(91)90030-G

1. 1. To characterize the development of peptide hydrolysis the activities of pancreatic carboxypeptidase A (CPA) and intestinal glycylleucine dipeptidase (GLDP) were registered in 1–45 days old chicks, as well as GLDP activities in newborn and adult guinea pigs. 2. 2. The highest values of CPA and GLDP relative activities were found immediately after hatching, maximal decrease of activities took place during the first week. 3. 3. GLDP activities gradient on the surface of the small intestine of chicks has two maximums: one in the upper jejunum, the other one—in the lower ileum. The development of proximo-distal gradient began at the age of 7 days and finished at the end of the first month. 4. 4. Total CPA and GLDP activities decreased during the first week; up to the 15–20 day they reached the initial level and later exceeded it. 5. 5. Relative GLDP activity in guinea pigs declined with aging, while the total activity increased, as it was demonstrated for chicks. 6. 6. GLDP activity was distributed equally along the surface of the small intestine in newborn guinea pigs as well as in mature animals.