LINC01134: a pivotal oncogene with promising predictive maker and therapeutic target in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) represents a leading and fatal malignancy within the gastrointestinal tract. Recent advancements highlight the pivotal role of long non-coding RNAs (lncRNAs) in diverse biological pathways and pathologies, particularly in tumorigenesis. LINC01134, a particular lncRNA,...

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Published inFrontiers in oncology Vol. 14; p. 1265762
Main Authors Yu, Yutian, Wang, Jialing, Guo, Qingfa, Luo, Hongliang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 21.02.2024
Subjects
hepatocellular carcinoma
LINC01134
Oncology
therapeutic target
tumor biomarker
tumorigenesis
therapeutic target
LINC01134
tumorigenesis
tumor biomarker
hepatocellular carcinoma
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Summary:Hepatocellular carcinoma (HCC) represents a leading and fatal malignancy within the gastrointestinal tract. Recent advancements highlight the pivotal role of long non-coding RNAs (lncRNAs) in diverse biological pathways and pathologies, particularly in tumorigenesis. LINC01134, a particular lncRNA, has attracted considerable attention due to its oncogenic potential in hepatoma. Current research underscores LINC01134’s potential in augmenting the onset and progression of HCC, with notable implications in drug resistance. This review comprehensively explores the molecular functions and regulatory mechanisms of LINC01134 in HCC, offering a fresh perspective for therapeutic interventions. By delving into LINC01134’s multifaceted roles, we aim to foster novel strategies in HCC management.
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Reviewed by: Patricia Schoenlein, Augusta University, United States
Jiwei Zhang, Shanghai University of Traditional Chinese Medicine, China
These authors have contributed equally to this work
Edited by: John Gibbs, Hackensack Meridian Health, United States
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2024.1265762