Growth Hormone (GH) Therapy During the Transition Period: Should We Think about Early Retesting in Patients with Idiopathic and Isolated GH Deficiency?

• Published in: International journal of environmental research and public health Vol. 16; no. 3; p. 307
• Main Authors: Penta, Laura, Cofini, Marta, Lucchetti, Laura, Zenzeri, Letizia, Leonardi, Alberto, Lanciotti, Lucia, Galeazzi, Daniela, Verrotti, Alberto, Esposito, Susanna
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.01.2019; MDPI
• Subjects: Adolescent; Adults; Age; Arginine - administration & dosage; Body composition; Child; Child, Preschool; Cholesterol; Drug Monitoring - methods; Drug Monitoring - standards; Dwarfism, Pituitary - drug therapy; Endocrinology; Female; Growth Hormone - therapeutic use; Growth Hormone-Releasing Hormone - administration & dosage; Growth hormones; Homeostasis; Hormone Replacement Therapy - methods; Human Growth Hormone - blood; Human Growth Hormone - deficiency; Humans; Insulin; Insulin resistance; Insulin-Like Growth Factor I - metabolism; Insulin-like growth factors; Male; Males; Medical Overuse - prevention & control; Metabolism; NMR; Nuclear magnetic resonance; Physiology; Pituitary gland; Italy; growth hormone retesting; growth hormone deficiency; transition age
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph16030307

To investigate growth hormone (GH) secretion at the transition age, retesting of all subjects who have undergone GH replacement therapy is recommended when linear growth and pubertal development are complete to distinguish between transitional and persistent GH deficiency (GHD). Early retesting of c...