Intracisternal administration of COX inhibitors attenuates mechanical allodynia following compression of the trigeminal ganglion in rats

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 33; no. 4; pp. 589 - 595
• Main Authors: Yang, Gwi Y., Lee, Min K., Bae, Yong C., Ahn, Dong K.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 15.06.2009; Elsevier
• Subjects: Allodynia; Analysis of Variance; Animal model; Animals; Biological and medical sciences; Body Weight - physiology; COX; Cyclooxygenase Inhibitors - pharmacology; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Face - innervation; Hyperalgesia - drug therapy; Hyperalgesia - etiology; Male; Medical sciences; Neuropharmacology; Pain Measurement; Pain Threshold - drug effects; Pharmacology. Drug treatments; Rats; Rats, Sprague-Dawley; Time Factors; Trigeminal ganglion; Trigeminal Ganglion - pathology; Trigeminal Nerve Diseases - complications; Trigeminal neuralgia; Allodynia; Animal model; Trigeminal neuralgia; PE; PG; i.m; MAPK; Trigeminal ganglion; COX; Prostaglandin-endoperoxide synthase; Rat; Indometacin; Cyclooxygenase 2 inhibitor; Trigeminal Neuralgia; Tocolytic; Indoleacetic acid derivatives; Peripheral nervous system; Nociception; Nervous system diseases; Enzyme; Stomatology; Intracisternal administration; Rodentia; Enzyme inhibitor; Cyclooxygenase 1 inhibitor; Non steroidal antiinflammatory agent; Vertebrata; Mammalia; Animal; Inhibitor; Oxidoreductases
• ISSN: 0278-5846; 1878-4216
• DOI: 10.1016/j.pnpbp.2009.02.010

The purpose of the present study was to investigate the role of central cyclooxygenase (COX) pathways in the modulation of mechanical allodynia following compression of the left trigeminal ganglion. Experiments were carried out on male Sprague–Dawley rats mounted onto a stereotaxic frame under anesthesia. For compression, a 4% agar solution (10 μl) was injected into the trigeminal ganglion. In the control group, rats were sham operated without agar injections. Ipsilateral and contralateral air-puff thresholds significantly decreased following trigeminal ganglion compression. Mechanical allodynia was established within 3 days and lasted beyond postoperative day 30, returning to preoperative levels at approximately 55 days following compression. Intracisternal administration of indomethacin, a non-selective COX inhibitor, SC-560, a selective COX-1 inhibitor, or NS-398, a selective COX-2 inhibitor, significantly inhibited mechanical allodynia. The individual anti-allodynic effects of the three COX inhibitors persisted for 6 h and returned to pretreatment values within 24 h. Based on these results, the blockade of central COX pathways may comprise a potential new therapeutic tool for the treatment of trigeminal ganglion compression-induced nociception.