Hositisines A and B, new alkaloids from the stems of Ormosia hosiei Hemsl. et Wils

Two new alkaloids, named hositisines A (1) and B (2), with two known alkaloids (3 and 4) were isolated from the stems of Ormosia hosiei Hemsl. et Wils. Their structures were confirmed by UV, HRESIMS, NMR spectra. The absolute configurations of 1 and 2 were determined by quantum ECD calculation and E...

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Published inNatural product research Vol. 35; no. 13; pp. 2184 - 2189
Main Authors Ni, Lin, Chen, Jingxin, Zhang, Xiaoqin, Wu, Meiting, Zhang, Linjing, Wu, Zujian, Huang, Mingqing, Xu, Huiyou
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis 01.07.2021
Taylor & Francis Ltd
Subjects
alkaloid
Alkaloids
Deprivation
LDH release
NMR
Nuclear magnetic resonance
OGD
Ormosia
Ormosia hosiei
PC12
Pheochromocytoma cells
Stems
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Summary:Two new alkaloids, named hositisines A (1) and B (2), with two known alkaloids (3 and 4) were isolated from the stems of Ormosia hosiei Hemsl. et Wils. Their structures were confirmed by UV, HRESIMS, NMR spectra. The absolute configurations of 1 and 2 were determined by quantum ECD calculation and ECD, respectively. Compounds 1-3 could significantly reduce the LDH release at the concentration 50 μM, which showed they could strongly protect the PC12 cells exposed to oxygen and glucose deprivation/reoxygenation (OGD/R) injury.
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1666387